Biology (AKU-BIO)
Topic 2 of 7Aga Khan Board

Human Body Systems

Circulatory, digestive and respiratory systems

Circulatory System:

The heart is a double pump. Right side pumps deoxygenated blood to the lungs. Left side pumps oxygenated blood to the body.

  • Arteries: thick-walled, carry blood away from heart, high pressure
  • Veins: thinner walls, carry blood to heart, have valves to prevent backflow
  • Capillaries: one cell thick, allow exchange of oxygen, nutrients and CO₂

  • Digestive System (mouth to anus):

    Mouth (chewing + amylase) → oesophagus → stomach (HCl + protease) → small intestine (absorption of nutrients via villi — large surface area, thin walls, rich blood supply) → large intestine (water absorption) → rectum → anus.


    Respiratory System:

    Air: nose → trachea → bronchi → bronchioles → alveoli (gas exchange).

    Alveoli have: large surface area, thin walls (one cell thick), moist, good blood supply → efficient diffusion of O₂ into blood, CO₂ out.

    Breathing in (inspiration): diaphragm contracts (flattens), rib cage rises → lung volume increases → pressure drops → air enters.

    Breathing out (expiration): diaphragm relaxes, rib cage falls → air expelled.

    Key Points to Remember

    • 1Arteries: away from heart; veins: to heart (have valves)
    • 2Small intestine villi: large surface area for absorption
    • 3Alveoli: large surface area, thin walls for gas exchange
    • 4Inspiration: diaphragm contracts, lung volume increases

    Pakistan Example

    Shaukat Khanum Hospital — Human Systems and Cancer Treatment

    Shaukat Khanum Memorial Cancer Hospital in Lahore treats lung cancer (respiratory system), bowel cancer (digestive system), and heart disease (circulatory system). AKU-EB Biology questions often use Pakistani hospital contexts. Understanding the structure of alveoli explains why smoking causes cancer — tar destroys the thin alveolar walls reducing gas exchange efficiency.

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